A few people I know from the Nexus forums and I have found a bit of trouble with the ENB for Skyrim in combination with the new 10** serie cards from Nvidea. The d3d9.dll doesn't work (makes the game crash on loading ENB). We sometimes can make it work by deleting the d3d9.dll and replacing it with the injector version, this doesn't seem to work all the time, but when it does, FPS drops horribly. When changing heavy things from for the engine, like putting uGrids higher, no FPS differences appear. Only things that affect how heavy ENB runs make a difference. as last, my mod list runs smoothly on people with a 980, but on my 1080 it's having a hard time, running between 60(capped) frames and 35. People who have reported problems have either an 1070 or 1080. Is there any update planned for the 10** series, or is this ad least a known issue?
I have not checked with other games as I don't run other games with ENB beside Oblivion, which I haven't been able to test just yet.